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Oral aloe vera may reduce fasting blood glucose in type 2 diabetes

   
09:56' AM - Thứ sáu, 08/07/2016
Oral aloe vera may reduce fasting blood glucose in type 2 diabetes
Dick WR, et al. J Altern Complement Med. 2016;doi:10.1089/acm.2015.0122.
July 5, 2016
Consumption of oral aloe vera may reduce both fasting blood glucose and HbA1c in adults with prediabetes and type 2 diabetes, with increased benefits for those with a fasting blood glucose of at least 200 mg/dL, according to a recent meta-analysis.
William R. Dick, Pharm D, of the department of pharmacy at the David Grant USAF Medical Center at Travis Air Force Base in Fairfield, California, and colleagues analyzed data from nine studies assessing the effectiveness of oral aloe vera consumption on fasting blood glucose and HbA1c in adults with prediabetes or type 2 diabetes. All nine studies had fasting blood glucose data (n = 283); five studies had HbA1c data (n = 89). In three studies, aloe vera juice preparations were used; one study used aloe gel; four used powdered aloe gel capsules and one used dried aloe latex resin. Researchers measured changes in fasting blood glucose and HbA1c as weighted mean differences from baseline.
Across studies, adults who consumed oral aloe vera saw a mean fasting blood glucose decrease of 46.6 mg/dL (95% CI, –66.54 to –26.74); HbA1c decreased by a mean of 1.05% (95% CI, –1.78 to –0.33). Egger statistic models showed publication bias with fasting blood glucose (P = .01) but not with HbA1c (P = .602).
In subgroup analysis, results persisted after excluding one study suggesting a substantially greater benefit, with a weighted mean difference of –42.9 mg/dL for fasting blood glucose (95% CI, –63.09 to –22.7) and of –0.98% for HbA1c (95% CI, –1.72 to –0.23).
Data from an analysis of four trials whose populations had a fasting blood glucose of at least 200 mg/dL suggested an increased benefit from oral aloe vera consumption vs. those with a fasting blood glucose of less than 200 mg/dL; this population experienced a mean fasting blood glucose reduction of 109.9 mg/dL (95% CI, –142.1 to –77.7).
The researchers noted several limitations in the analysis, including different formulations and doses of aloe vera products used, a range in duration from 4 to 14 weeks, and small sample sizes in all trials.
“The results of this meta-analysis support the use of oral aloe vera for significantly reducing both [fasting blood glucose] (46.6 mg/dL) and HbA1c (1.05%) in prediabetic and diabetic patients,” the researchers wrote. “However, given the current overall quality and relative scarcity of data, further clinical studies that are more robust and better controlled are warranted to confirm and further explore these findings.” – by Regina Schaffer
Disclosure: The researchers report no relevant financial disclosures.


Số lượt đọc:  13  -  Cập nhật lần cuối:  08/07/2016 09:59:32 AM
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